Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 14/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 14/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 14/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 11/20 | 0.39 |
| ▸ | TSHR | P16473 | 11/20 | 0.39 |
| ▸ | LMNA | P02545 | 7/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 13/20 | 0.38 |
| ▸ | MEN1 | O00255 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | USP2 | O75604 | 5/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29844225 | 1.00 | EGFR (0.43) | EGFRALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL23217009 | 0.86 | ALDH1A1 (0.42) | EGFRALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL29844240 | 0.86 | ALDH1A1 (0.42) | EGFRALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL25230775 | 0.86 | ALDH1A1 (0.42) | EGFRALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL25273546 | 0.82 | EGFR (0.55) | EGFRBTK | |
| SCHEMBL21903643 | 0.81 | BTK (0.46) | EGFRMAPTBTK | |
| SCHEMBL21903789 | 0.81 | BTK (0.52) | EGFRBTK | |
| SCHEMBL21903785 | 0.81 | BTK (0.52) | EGFRBTK | |
| SCHEMBL24096641 | 0.78 | TP53 (0.41) | EGFRALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL29998774 | 0.78 | TP53 (0.41) | EGFRALDH1A1CYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230058545-A1 | HCK AS A THERAPEUTIC TARGET IN MYD88 MUTATED DISEASES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-02-23 | — | — | US | disclosed |
| WO-2021071919-A1 | HCK AS A THERAPEUTIC TARGET IN MYD88 MUTATED DISEASES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-04-15 | — | — | WO | disclosed |
| WO-2021071919-A1 | HCK AS A THERAPEUTIC TARGET IN MYD88 MUTATED DISEASES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230058545-A1 | HCK AS A THERAPEUTIC TARGET IN MYD88 MUTATED DISEASES | HCK, LYN, BTK | EGFR 576/4885ALDH1A1 4815/4885CYP1A2 3818/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.