Sugi Predict

Sugi Predict / Compounds / SCHEMBL23217650

SCHEMBL23217650

SCHEMBL23217650

CCOC(=O)Cc1ccc(CCO)cc1OCc1cc(-c2cccc(CN)c2)c2occc2c1

nearest known ligand 0.59

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ CFD P00746 18/20 0.59
▸ PLG P00747 1/20 0.40
▸ PLAU P00749 1/20 0.40
▸ F11 P03951 1/20 0.40
▸ KLKB1 P03952 1/20 0.40
▸ F7 P08709 1/20 0.40
▸ TPSB2 P20231 1/20 0.40
▸ SYK P43405 1/20 0.34
▸ PDCD1 Q15116 1/20 0.34
▸ CD274 Q9NZQ7 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21437517 0.95 CFD (0.65) CFDPLGPLAUF11KLKB1
SCHEMBL21437990 0.94 CFD (0.60) CFDPLGPLAUF11KLKB1
SCHEMBL21437710 0.94 CFD (0.61) CFDPLGPLAUF11KLKB1
SCHEMBL21437432 0.93 CFD (0.62) CFDPLGPLAUF11KLKB1
SCHEMBL21438363 0.91 CFD (0.64) CFDPLGPLAUF11KLKB1
SCHEMBL21438841 0.90 CFD (0.62) CFDPLGPLAUF11KLKB1
SCHEMBL23217630 0.89 CFD (0.73) CFDPLGPLAUF11KLKB1
SCHEMBL21438480 0.89 CFD (0.61) CFDPLGPLAUF11KLKB1
SCHEMBL21437301 0.89 CFD (0.63) CFDPLGPLAUF11KLKB1
SCHEMBL21437984 0.89 CFD (0.63) CFDPLGPLAUF11KLKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021072156-A1 ORAL COMPLEMENT FACTOR D INHIBITORS BIOCRYST PHARMACEUTICALS, INC. (US) 2021-04-15 — — WO disclosed