Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 9/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29987401 | 1.00 | TNF (0.39) | TNFEGLN1RIPK1PTPN11AOC3 | |
| SCHEMBL18151583 | 0.88 | AOC3 (0.43) | TNFAOC3CNR2CYP1A2CYP2C9 | |
| SCHEMBL18151733 | 0.88 | TNF (0.40) | TNFRIPK1AOC3 | |
| SCHEMBL29794997 | 0.88 | AOC3 (0.43) | TNFAOC3CNR2CYP1A2CYP2C9 | |
| SCHEMBL16814754 | 0.88 | AOC3 (0.43) | TNFAOC3CNR2CYP1A2CYP2C9 | |
| SCHEMBL18151311 | 0.88 | AOC3 (0.43) | TNFAOC3CNR2CYP1A2CYP2C9 | |
| SCHEMBL29794831 | 0.87 | TNF (0.41) | TNFRIPK1AOC3 | |
| SCHEMBL18159822 | 0.87 | TNF (0.41) | TNFRIPK1AOC3 | |
| SCHEMBL18153352 | 0.86 | TNF (0.35) | TNFEGLN1PTPN11AOC3 | |
| SCHEMBL18150951 | 0.84 | TNF (0.38) | TNFRIPK1AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021072269-A1 | TARGETED BIFUNCTIONAL DEGRADERS | YALE UNIVERSITY (US) | 2021-04-15 | — | — | WO | disclosed |