SCHEMBL23217860

SCHEMBL23217860

CCOC(=O)Cc1ccccc1OCc1cc(-c2cccc(CN)c2)c2occc2c1OCC(=O)O

nearest known ligand 0.51

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CFD P00746 19/20 0.51
TPSB2 P20231 4/20 0.49
F11 P03951 3/20 0.49
PLG P00747 1/20 0.49
PLAU P00749 1/20 0.49
KLKB1 P03952 1/20 0.49
F7 P08709 1/20 0.49
PTGER1 P34995 1/20 0.37
PTGER4 P35408 1/20 0.37
PTGER3 P43115 1/20 0.37
PTGER2 P43116 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23217268 0.92 CFD (0.51) CFDTPSB2F11PLGPLAU
SCHEMBL30010309 0.92 CFD (0.51) CFDTPSB2F11PLGPLAU
SCHEMBL30010535 0.91 CFD (0.50) CFDTPSB2F11PLGPLAU
SCHEMBL23217592 0.91 CFD (0.50) CFDTPSB2F11PLGPLAU
SCHEMBL28772722 0.91 CFD (0.60) CFDTPSB2F11PLGPLAU
SCHEMBL30009702 0.91 CFD (0.46) CFDTPSB2F11PLGPLAU
SCHEMBL28772704 0.91 CFD (0.46) CFDTPSB2F11PLGPLAU
SCHEMBL30010288 0.90 CFD (0.46) CFDTPSB2F11PLGPLAU
SCHEMBL23217477 0.89 CFD (0.49) CFDTPSB2F11PLGPLAU
SCHEMBL30010482 0.89 CFD (0.49) CFDTPSB2F11PLGPLAU

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021072156-A1 ORAL COMPLEMENT FACTOR D INHIBITORS BIOCRYST PHARMACEUTICALS, INC. (US) 2021-04-15 WO disclosed