Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 20/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24164370 | 0.96 | TGFBR1 (0.42) | TGFBR1MAPK14RIPK2KDRACVR1B | |
| SCHEMBL24164369 | 0.95 | TGFBR1 (0.42) | TGFBR1MAPK14RIPK2KDRACVR1B | |
| SCHEMBL24164469 | 0.89 | TGFBR1 (0.44) | TGFBR1MAPK14RIPK2KDRACVR1B | |
| SCHEMBL23217935 | 0.88 | TGFBR1 (0.43) | TGFBR1MAPK14RIPK2KDRACVR1B | |
| SCHEMBL24164432 | 0.86 | TGFBR1 (0.47) | TGFBR1MAPK14RIPK2KDRACVR1B | |
| SCHEMBL24164581 | 0.86 | TGFBR1 (0.59) | TGFBR1MAPK14RIPK2KDRACVR1B | |
| SCHEMBL23217951 | 0.85 | TGFBR1 (0.40) | TGFBR1MAPK14RIPK2KDRACVR1B | |
| SCHEMBL23217990 | 0.85 | SCN9A (0.40) | TGFBR1MAPK14RIPK2KDRACVR1B | |
| SCHEMBL24164339 | 0.83 | TGFBR1 (0.52) | TGFBR1MAPK14RIPK2KDRACVR1B | |
| SCHEMBL24164888 | 0.83 | TGFBR1 (0.48) | TGFBR1MAPK14RIPK2KDRACVR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022006340-A1 | ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF | SILVERBACK THERAPEUTICS, INC. (US) | 2022-01-06 | — | — | WO | disclosed |
| WO-2022006340-A1 | ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF | SILVERBACK THERAPEUTICS, INC. (US) | 2022-01-06 | — | — | WO | disclosed |
| WO-2021072330-A1 | GALNAC-TGFBR1 INHIBITOR CONJUGATES FOR THE TREATMENT OF LIVER DISEASES | SILVERBACK THERAPEUTICS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |