Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 10/20 | 0.42 |
| ▸ | SUCNR1 | Q9BXA5 | 5/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | CKS1B | P61024 | 1/20 | 0.32 |
| ▸ | SKP1 | P63208 | 1/20 | 0.32 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23217944 | 0.88 | TGFBR1 (0.48) | TGFBR1SUCNR1MTORRIPK2KDR | |
| SCHEMBL23217959 | 0.87 | TGFBR1 (0.41) | TGFBR1SUCNR1MTORRIPK2KDR | |
| SCHEMBL23217937 | 0.83 | TGFBR1 (0.38) | TGFBR1RIPK2KDRACVR1BMAPK14 | |
| SCHEMBL23217990 | 0.82 | SCN9A (0.40) | TGFBR1RIPK2KDRACVR1BMAPK14 | |
| SCHEMBL23217955 | 0.81 | TGFBR1 (0.41) | TGFBR1MAPK14 | |
| SCHEMBL24164908 | 0.81 | TGFBR1 (0.47) | TGFBR1MTORRIPK2KDRACVR1B | |
| SCHEMBL23217946 | 0.80 | TGFBR1 (0.37) | TGFBR1RIPK2KDRACVR1BMAPK14 | |
| SCHEMBL24164651 | 0.77 | TGFBR1 (0.37) | TGFBR1RIPK2KDRACVR1BMAPK14 | |
| SCHEMBL7550981 | 0.74 | TGFBR1 (0.54) | TGFBR1MTORRIPK2KDRACVR1B | |
| SCHEMBL23217942 | 0.74 | TGFBR1 (0.47) | TGFBR1MTORRIPK2KDRACVR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022006340-A1 | ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF | SILVERBACK THERAPEUTICS, INC. (US) | 2022-01-06 | — | — | WO | disclosed |
| WO-2022006340-A1 | ALK5 INHIBITORS, CONJUGATES, AND USES THEREOF | SILVERBACK THERAPEUTICS, INC. (US) | 2022-01-06 | — | — | WO | disclosed |
| WO-2021072330-A1 | GALNAC-TGFBR1 INHIBITOR CONJUGATES FOR THE TREATMENT OF LIVER DISEASES | SILVERBACK THERAPEUTICS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |