Sugi Predict

Sugi Predict / Compounds / SCHEMBL23218813

SCHEMBL23218813

SCHEMBL23218813

CCOC(=O)Cc1ccccc1OCc1nn(C(C)C)c2ccc(-c3ccnc(C#N)c3OC)cc12

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CFD P00746 1/20 0.39
▸ TBXAS1 P24557 1/20 0.36
▸ ICMT O60725 6/20 0.34
▸ HTT P42858 1/20 0.32
▸ HSD17B10 Q99714 1/20 0.32
▸ PTK2 Q05397 1/20 0.31
▸ MAPK8 P45983 1/20 0.31
▸ MAPK9 P45984 1/20 0.31
▸ MAPK10 P53779 1/20 0.31
▸ KDM4E B2RXH2 2/20 0.31
▸ ALDH1A1 P00352 2/20 0.31
▸ DPP4 P27487 2/20 0.31
▸ MEN1 O00255 1/20 0.31
▸ KMT2A Q03164 1/20 0.31
▸ RXFP1 Q9HBX9 1/20 0.31
▸ HPGD P15428 2/20 0.31
▸ GLA P06280 1/20 0.31
▸ GAA P10253 1/20 0.31
▸ MAPT P10636 1/20 0.31
▸ L3MBTL1 Q9Y468 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29852652 1.00 CFD (0.39) CFDTBXAS1ICMTHTTHSD17B10
SCHEMBL29121623 0.89 CFD (0.41) CFDTBXAS1ICMTHTTHSD17B10
SCHEMBL29852825 0.89 CFD (0.46) CFDTBXAS1ICMTPTK2KDM4E
SCHEMBL23219240 0.89 CFD (0.46) CFDTBXAS1ICMTPTK2KDM4E
SCHEMBL29340316 0.86 CFD (0.40) CFDTBXAS1ICMTHTTPTK2
SCHEMBL23218584 0.86 CFD (0.38) CFDTBXAS1ICMTMAPK8MAPK9
SCHEMBL23218867 0.86 CFD (0.38) CFDTBXAS1ICMTPTK2
SCHEMBL29852660 0.86 CFD (0.38) CFDTBXAS1ICMTMAPK8MAPK9
SCHEMBL29852529 0.86 CFD (0.38) CFDTBXAS1ICMTPTK2
SCHEMBL29123387 0.85 CFD (0.40) CFDTBXAS1ICMTHSD17B10KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12558341-B2 Oral complement factor D inhibitors BIOCRYST PHARMACEUTICALS, INC. (US) 2026-02-24 — — US disclosed
US-20250186391-A1 ORAL COMPLEMENT FACTOR D INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION 2025-06-12 — — US disclosed
US-20240239752-A1 BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 WILMINGTON TRUST, NATIONAL ASSOCIATION 2024-07-18 — — US disclosed
US-20240239752-A1 BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 WILMINGTON TRUST, NATIONAL ASSOCIATION 2024-07-18 — — US disclosed
CN-117120419-A KLK5 bicyclic heteroaromatic inhibitors 拜奥克里斯特制药公司 2023-11-24 — — CN disclosed
CN-114502168-A Oral complement factor D inhibitors 拜奥克里斯特制药公司 2022-05-13 — — CN disclosed
WO-2021072198-A1 ORAL COMPLEMENT FACTOR D INHIBITORS BIOCRYST PHARMACEUTICALS, INC. (US) 2021-04-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240239752-A1 BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 KLK5, KLK1, KLKB1 CFD 3529/4885TBXAS1 2084/4885ICMT 4826/4885
US-12558341-B2 Oral complement factor D inhibitors CFD, CFH, CFB CFD 1/4885TBXAS1 963/4885ICMT 4111/4885
US-20250186391-A1 ORAL COMPLEMENT FACTOR D INHIBITORS CFD, CFH, CFB CFD 1/4885TBXAS1 392/4885ICMT 3795/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.