Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 10/20 | 0.45 |
| ▸ | F11 | P03951 | 3/20 | 0.41 |
| ▸ | TPSB2 | P20231 | 2/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.37 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | MELK | Q14680 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29853135 | 1.00 | CFD (0.45) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL23218519 | 0.92 | CFD (0.51) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL29852973 | 0.92 | CFD (0.51) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL29852754 | 0.92 | CFD (0.48) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL23218099 | 0.92 | CFD (0.48) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL23219114 | 0.89 | CFD (0.52) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL29853180 | 0.89 | CFD (0.52) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL23218079 | 0.88 | CFD (0.52) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL29852554 | 0.88 | CFD (0.52) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL23218778 | 0.87 | CD274 (0.40) | CFDCD274PDCD1SUCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114502168-A | Oral complement factor D inhibitors | 拜奥克里斯特制药公司 | 2022-05-13 | — | — | CN | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |