Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 7/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | LSS | P48449 | 2/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20940088 | 0.94 | BCHE (0.35) | BCHESPHK1HRH3LSSPIM1 | |
| SCHEMBL20781658 | 0.90 | SPHK1 (0.34) | BCHESPHK1 | |
| SCHEMBL20781650 | 0.90 | SPHK1 (0.34) | BCHESPHK1 | |
| SCHEMBL23844606 | 0.90 | SPHK1 (0.34) | BCHESPHK1 | |
| SCHEMBL21440024 | 0.83 | GPR84 (0.34) | SPHK1 | |
| SCHEMBL24040221 | 0.82 | SPHK1 (0.38) | BCHESPHK1 | |
| SCHEMBL19619621 | 0.82 | SPHK1 (0.38) | BCHESPHK1 | |
| SCHEMBL20094680 | 0.82 | SPHK1 (0.38) | BCHESPHK1 | |
| SCHEMBL19629821 | 0.82 | HRH3 (0.35) | HRH3PIM1 | |
| SCHEMBL24087947 | 0.79 | MAPT (0.44) | BCHELSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10975088-B2 | Imidazo[2,1-f][1,2,4]triazine compounds as pi3k-y inhibitors | INCYTE CORPORATION (US) | 2021-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10975088-B2 | Imidazo[2,1-f][1,2,4]triazine compounds as pi3k-y inhibitors | PIK3R5, PIK3CD, PIK3CA | BCHE 4630/4885SPHK1 820/4885HRH3 3898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.