Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2318205 | 0.88 | MAP4K4 (0.41) | MAP4K4ESR1ESR2FFAR4PTGS2 | |
| SCHEMBL2317793 | 0.87 | MAP4K4 (0.39) | MAP4K4ESR1ESR2FFAR4PTGS2 | |
| SCHEMBL2319332 | 0.83 | MAP4K4 (0.49) | MAP4K4ESR1ESR2FFAR4PTGS2 | |
| SCHEMBL2320304 | 0.83 | MAPT (0.43) | MAP4K4PTGS2PTGS1MAPTALDH1A1 | |
| SCHEMBL2318319 | 0.81 | ESR1 (0.52) | ESR1ESR2FFAR4PTGS2CNR1 | |
| SCHEMBL2318109 | 0.78 | PTGS2 (0.46) | ESR1ESR2FFAR4PTGS2MAPT | |
| SCHEMBL2321253 | 0.77 | PTGS2 (0.43) | ESR1ESR2FFAR4PTGS2PSEN1 | |
| SCHEMBL2317325 | 0.77 | ESR1 (0.48) | ESR1ESR2FFAR4PTGS2PTGS1 | |
| SCHEMBL2319847 | 0.77 | ESR1 (0.48) | ESR1ESR2FFAR4PTGS2PTGS1 | |
| SCHEMBL2318956 | 0.76 | ESR1 (0.47) | ESR1ESR2FFAR4PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170873-B1 | ISOXAZOLE-IMIDAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-08-10 | — | — | EP | disclosed |