Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 4/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.37 |
| ▸ | TNF | P01375 | 2/20 | 0.37 |
| ▸ | IL1B | P01584 | 2/20 | 0.37 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.37 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23226143 | 0.81 | CRBN (0.59) | CRBNDDB1TNFIL1BIKZF1 | |
| SCHEMBL9988737 | 0.74 | DDB1 (0.64) | HTR2BTMEM97HTR3EHTR3BHTR3A | |
| SCHEMBL22939207 | 0.73 | DDB1 (0.39) | HTR2BTMEM97HTR3EHTR3BHTR3A | |
| SCHEMBL18263931 | 0.71 | DDB1 (0.63) | HTR2BTMEM97HTR3EHTR3BHTR3A | |
| SCHEMBL18270883 | 0.71 | DDB1 (0.63) | HTR2BTMEM97HTR3EHTR3BHTR3A | |
| SCHEMBL845434 | 0.70 | CRBN (0.57) | HTR2BTMEM97HTR3EHTR3BHTR3A | |
| SCHEMBL22006041 | 0.69 | TSHR (0.41) | HTR2BCRBNDDB1IKZF3KDM4E | |
| SCHEMBL22845577 | 0.69 | DDB1 (0.67) | HTR2BTMEM97HTR3EHTR3BHTR3A | |
| SCHEMBL18263930 | 0.69 | CRBN (0.65) | HTR2BTMEM97HTR3EHTR3BHTR3A | |
| SCHEMBL22873882 | 0.69 | CRBN (0.51) | CRBNDDB1TNFIL1BIKZF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021068380-A1 | PREPARATION OF DEGRADATION COMPOUND TARGETING BTK PROTEIN, AND APPLICATION THEREOF IN TREATING AUTOIMMUNE DISEASES AND TUMORS | 清华大学 | 2021-04-15 | — | — | WO | disclosed |