Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 16/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16651641 | 0.75 | BRD4 (0.58) | BRD4L3MBTL1BRD9BRD7 | |
| SCHEMBL29613217 | 0.75 | BRD4 (0.58) | BRD4L3MBTL1BRD9BRD7 | |
| SCHEMBL21224811 | 0.73 | BRD4 (0.37) | BRD4L3MBTL1BRD9BRD7 | |
| SCHEMBL28635546 | 0.71 | BRD4 (0.34) | BRD4L3MBTL1 | |
| SCHEMBL20155328 | 0.69 | HTT (0.41) | BRD4BRD9 | |
| SCHEMBL28520363 | 0.69 | HTT (0.38) | BRD4L3MBTL1BRD9 | |
| SCHEMBL19770707 | 0.69 | BRD9 (0.42) | BRD4L3MBTL1BRD9BRD7 | |
| SCHEMBL15069186 | 0.69 | BRD4 (0.37) | BRD4 | |
| SCHEMBL16651059 | 0.69 | BRD9 (0.46) | BRD4L3MBTL1BRD9BRD7 | |
| SCHEMBL15069208 | 0.69 | BRD4 (0.58) | BRD4BRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114401964-B | Compound with BRD4 inhibitory activity, preparation method and application thereof | 上海海和药物研究开发股份有限公司 | 2024-10-01 | — | — | CN | disclosed |
| CN-114401964-A | Compound with BRD4 inhibitory activity, preparation method and application thereof | 上海海和药物研究开发股份有限公司 | 2022-04-26 | — | — | CN | disclosed |
| WO-2021068755-A1 | COMPOUND HAVING BRD4 INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海海和药物研究开发股份有限公司 | 2021-04-15 | — | — | WO | disclosed |