SCHEMBL28635546

SCHEMBL28635546

Cn1cc(Br)c2c(C(=O)O)[nH]cc2c1=O

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 7/20 0.34
L3MBTL1 Q9Y468 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23212216 0.82 GABRA1 (0.38) BRD4L3MBTL1
SCHEMBL23233752 0.71 BRD4 (0.38) BRD4L3MBTL1
SCHEMBL31371423 0.70 BRD4 (0.38) BRD4L3MBTL1
SCHEMBL22442976 0.70 GPR35 (0.43) BRD4
SCHEMBL15964521 0.67 BRD4 (0.43) BRD4
SCHEMBL3450311 0.65 GPR35 (0.37) BRD4L3MBTL1
SCHEMBL21224824 0.65 BRD4 (0.43) BRD4L3MBTL1
SCHEMBL22289905 0.64 BRD4 (0.40) BRD4
SCHEMBL28719291 0.64 MAP2K1 (0.34) BRD4L3MBTL1
SCHEMBL17975213 0.64 KMT2A (0.39) BRD4L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114401964-A Compound with BRD4 inhibitory activity, preparation method and application thereof 上海海和药物研究开发股份有限公司 2022-04-26 CN disclosed
CN-112625036-A Compound with BRD4 inhibitory activity, preparation method and application thereof 上海海和药物研究开发股份有限公司 2021-04-09 CN disclosed