Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.43 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.43 |
| ▸ | TDP2 | O95551 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3440731 | 0.73 | ALDH1A1 (0.69) | MAPTKDM4EALDH1A1TDP1BLM | |
| Hydrochloric Acid SCHEMBL7560518 | 0.71 | ALDH1A1 (0.67) | MAPTKDM4EALDH1A1TDP1BLM | |
| SCHEMBL29589725 | 0.70 | ALDH1A1 (0.59) | MAPTKDM4EALDH1A1 | |
| SCHEMBL1026913 | 0.70 | ALDH1A1 (0.59) | MAPTKDM4EALDH1A1 | |
| SCHEMBL30428318 | 0.70 | ALDH1A1 (0.59) | MAPTKDM4EALDH1A1 | |
| SCHEMBL1026101 | 0.70 | ALDH1A1 (0.59) | MAPTKDM4EALDH1A1 | |
| SCHEMBL9477896 | 0.69 | ALDH1A1 (0.83) | MAPTKDM4EALDH1A1TDP1BLM | |
| SCHEMBL24400674 | 0.69 | KDM4E (0.62) | MAPTKDM4EALDH1A1TDP1BLM | |
| Hydrochloric Acid SCHEMBL15671006 | 0.69 | ALDH1A1 (0.58) | MAPTKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL22654009 | 0.69 | ALDH1A1 (0.58) | MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3807268-A1 | PROCESS FOR THE PREPARATION OF LIFITEGRAST | OLON S.p.A. (IT) | 2021-04-21 | — | — | EP | disclosed |