Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.82 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.82 |
| ▸ | MEN1 | O00255 | 5/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.80 |
| ▸ | RAD52 | P43351 | 2/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23234985 | 0.95 | RXFP1 (1.00) | RXFP1MAPK1KDM4EHSD17B10MEN1 | |
| SCHEMBL23235009 | 0.92 | RXFP1 (0.85) | RXFP1MAPK1KDM4EHSD17B10MEN1 | |
| SCHEMBL20435773 | 0.91 | MEN1 (0.88) | RXFP1MAPK1KDM4EHSD17B10MEN1 | |
| SCHEMBL31087724 | 0.90 | MEN1 (0.89) | RXFP1MAPK1KDM4EHSD17B10MEN1 | |
| Hydrochloric Acid SCHEMBL31087693 | 0.89 | MEN1 (1.00) | RXFP1MAPK1KDM4EHSD17B10MEN1 | |
| SCHEMBL23234995 | 0.85 | RXFP1 (0.75) | RXFP1MAPK1KDM4EHSD17B10MEN1 | |
| SCHEMBL5329573 | 0.85 | KMT2A (1.00) | RXFP1MAPK1KDM4EHSD17B10MEN1 | |
| SCHEMBL12504994 | 0.84 | RXFP1 (0.80) | RXFP1MAPK1KDM4EHSD17B10MEN1 | |
| SCHEMBL23235039 | 0.84 | MAPK1 (0.72) | RXFP1MAPK1KDM4EHSD17B10MEN1 | |
| SCHEMBL23634687 | 0.83 | RXFP1 (0.74) | RXFP1MAPK1KDM4EHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12172991-B2 | Bicycle topoisomerase i inhibiting compounds, process for preparation and use thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2024-12-24 | — | — | US | disclosed |
| US-20210246128-A1 | BICYCLE TOPOISOMERASE I INHIBITING COMPOUNDS, PROCESS FOR PREPARATION AND USE THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2021-08-12 | — | — | US | disclosed |
| EP-3807248-A1 | BICYCLE TOPOISOMERASE I INHIBITING COMPOUNDS, PROCESS FOR PREPARATION AND USE THEREOF | Council of Scientific and Industrial Research (IN) | 2021-04-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12172991-B2 | Bicycle topoisomerase i inhibiting compounds, process for preparation and use thereof | TOP1, TOP2A, TOP2B | RXFP1 4661/4885MAPK1 1850/4885KDM4E 2680/4885 |
| US-20210246128-A1 | BICYCLE TOPOISOMERASE I INHIBITING COMPOUNDS, PROCESS FOR PREPARATION AND USE THEREOF | TOP1, TOP2A, TOP2B | RXFP1 4661/4885MAPK1 1850/4885KDM4E 2680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.