⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28358909 | 0.97 | GAA (0.50) | — | |
| SCHEMBL28745990 | 0.97 | GAA (0.50) | — | |
| SCHEMBL28342310 | 0.97 | GAA (0.50) | — | |
| SCHEMBL26684 | 0.97 | — | — | |
| Lithium SCHEMBL30387988 | 0.93 | — | — | |
| SCHEMBL6500325 | 0.93 | — | — | |
| SCHEMBL28869078 | 0.93 | — | — | |
| Ammonia Solution, Strong SCHEMBL6253681 | 0.93 | — | — | |
| Hydrochloric Acid SCHEMBL4434111 | 0.93 | — | — | |
| Phosphine SCHEMBL11162239 | 0.93 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839128-B1 | PROCESS FOR THE PREPARATION OF ETHYL 3S-[[4-[[4-(AMINOIMINOMETHYL)PHENYL]AMINO]-1,4-DIOXOBUTYL]AMINO]-4-PENTYNOATE | SEARLE & CO (US) | 2000-04-05 | — | — | EP | claimed |
| EP-0839128-A1 | PROCESS FOR THE PREPARATION OF ETHYL 3S-[[4-[[4-(AMINOIMINOMETHYL)PHENYL]AMINO]-1,4-DIOXOBUTYL]AMINO]-4-PENTYNOATE | G.D. SEARLE & CO. (US) | 1998-05-06 | — | — | EP | claimed |
| US-5631399-A | MULTISTAGE SYNTHESIS USING TRIMETHYLSILYLACETYLENE WITH BUTYLLITHIUM AND FORMYLMORPHOLINE, THEN ACID HYDROLYSIS | G. D. SEARLE & CO. (US) | 1997-05-20 | — | — | US | claimed |
| WO-1997003947-A1 | PROCESS FOR THE PREPARATION OF ETHYL 3S-[[4-[[4-(AMINOIMINOMETHYL)PHENYL]AMINO]-1,4-DIOXOBUTYL]AMINO]-4-PENTYNOATE | G.D. SEARLE & CO. (US) | 1997-02-06 | — | — | WO | claimed |
| US-5536869-A | Process for the preparation of ethyl 3S-[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-pentynoate | G. D. SEARLE & CO. (US) | 1996-07-16 | — | — | US | claimed |
| US-5075448-A | Synthesis of swainsonine and analogs thereof | MONSANTO COMPANY (US) | 1991-12-24 | — | — | US | claimed |
| CN-112430197-B | Synthesis method of 3-oxo-5-hydroxy-6-cyano tert-butyl caproate | 江苏阿尔法药业股份有限公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-107669669-A | novel glucagon receptor antagonist | 症变治疗公司 | 2018-02-09 | — | — | CN | disclosed |
| CN-101610995-B | Glucagon receptor antagonists | 症变治疗公司 | 2017-08-08 | — | — | CN | disclosed |
| CN-105566265-A | Antagonists of the glucagon receptor | METABASIS THERAPEUTICS INC | 2016-05-11 | — | — | CN | disclosed |
| US-8785690-B2 | Thioamide compound, method for producing thioamide compound, method for producing [(4R,6R)-6-aminoethyl-1,3-dioxan-4-yl]acetate derivative, and method for producing atorvastatin | MICROBIAL CHEMISTRY RESEARCH FOUNDATION (JP) | 2014-07-22 | — | — | US | disclosed |
| CN-101657432-B | Dihydro-benzo[B][1,4]diazepin-2-one sulfonamide derivatives | HOFFMANN LA ROCHE CH | 2013-04-10 | — | — | CN | disclosed |
| CN-102015658-B | Benzimidazole derivatives serving as calcium channel blocker | ACTELION PHARMACEUTICALS LTD | 2013-03-20 | — | — | CN | disclosed |
| US-5075448-A | Synthesis of swainsonine and analogs thereof | MONSANTO COMPANY (US) | 1991-12-24 | — | — | US | disclosed |
| US-5075457-A | Synthesis of swainsonine and analogs thereof | MONSANTO COMPANY (US) | 1991-12-24 | — | — | US | disclosed |
| US-5023340-A | Pyrrolizioines and synthesis thereof | MONSANTO COMPANY (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0424349-A1 | Synthesis of 1,4-dideoxy-1,4-imino-D-mannitol | MONSANTO COMPANY (US) | 1991-04-24 | — | — | EP | disclosed |
| CN-1038099-A | Alpha-adrenergic aceptor antagonist | SMITHKLINE BECKMAN CORP (US) | 1989-12-20 | — | — | CN | disclosed |
| CN-1038100-A | The method for preparing Alpha-Adrenergic receptor antagonist | SMITHKLINE BECKMAN CORP (US) | 1989-12-20 | — | — | CN | disclosed |
| EP-0244364-A2 | Preparation of olefinic compounds | SANDOZ AG (CH) | 1987-11-04 | — | — | EP | disclosed |