Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 12/20 | 0.75 |
| ▸ | LCK | P06239 | 9/20 | 0.75 |
| ▸ | SRC | P12931 | 7/20 | 0.75 |
| ▸ | TEK | Q02763 | 7/20 | 0.75 |
| ▸ | KDR | P35968 | 3/20 | 0.75 |
| ▸ | NUDT14 | O95848 | 2/20 | 0.63 |
| ▸ | NUDT5 | Q9UKK9 | 2/20 | 0.63 |
| ▸ | EGFR | P00533 | 4/20 | 0.57 |
| ▸ | LYN | P07948 | 2/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.57 |
| ▸ | ITK | Q08881 | 2/20 | 0.57 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.57 |
| ▸ | PLK4 | O00444 | 1/20 | 0.57 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.57 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.57 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.57 |
| ▸ | PAK4 | O96013 | 1/20 | 0.57 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23239684 | 1.00 | BTK (0.75) | BTKLCKSRCTEKKDR | |
| SCHEMBL29844235 | 1.00 | BTK (0.75) | BTKLCKSRCTEKKDR | |
| SCHEMBL23217530 | 1.00 | BTK (0.75) | BTKLCKSRCTEKKDR | |
| SCHEMBL5817702 | 0.92 | BTK (0.64) | BTKLCKSRCTEKKDR | |
| SCHEMBL5819015 | 0.89 | LCK (0.61) | BTKLCKSRCTEKKDR | |
| SCHEMBL5819558 | 0.87 | LCK (0.56) | BTKLCKSRCTEKKDR | |
| SCHEMBL6698204 | 0.86 | LCK (0.57) | BTKLCKSRCTEKKDR | |
| SCHEMBL6433141 | 0.86 | BTK (1.00) | BTKLCKSRCTEKKDR | |
| SCHEMBL6430567 | 0.86 | BTK (1.00) | BTKLCKSRCTEKKDR | |
| SCHEMBL29763088 | 0.86 | BTK (1.00) | BTKLCKSRCTEKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230058545-A1 | HCK AS A THERAPEUTIC TARGET IN MYD88 MUTATED DISEASES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-02-23 | — | — | US | disclosed |
| WO-2021071919-A1 | HCK AS A THERAPEUTIC TARGET IN MYD88 MUTATED DISEASES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230058545-A1 | HCK AS A THERAPEUTIC TARGET IN MYD88 MUTATED DISEASES | HCK, LYN, BTK | BTK 3/4885LCK 6/4885SRC 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.