Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 13/20 | 0.61 |
| ▸ | SRC | P12931 | 12/20 | 0.61 |
| ▸ | TEK | Q02763 | 11/20 | 0.61 |
| ▸ | BTK | Q06187 | 9/20 | 0.61 |
| ▸ | KDR | P35968 | 5/20 | 0.61 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.51 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.51 |
| ▸ | LYN | P07948 | 2/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.46 |
| ▸ | CSK | P41240 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29844235 | 0.89 | BTK (0.75) | LCKSRCTEKBTKKDR | |
| SCHEMBL23239685 | 0.89 | BTK (0.75) | LCKSRCTEKBTKKDR | |
| SCHEMBL23239684 | 0.89 | BTK (0.75) | LCKSRCTEKBTKKDR | |
| SCHEMBL23217530 | 0.89 | BTK (0.75) | LCKSRCTEKBTKKDR | |
| SCHEMBL5819012 | 0.88 | LCK (0.80) | LCKSRCTEKBTKKDR | |
| SCHEMBL6430220 | 0.88 | LCK (0.80) | LCKSRCTEKBTKKDR | |
| SCHEMBL5817702 | 0.82 | BTK (0.64) | LCKSRCTEKBTKKDR | |
| SCHEMBL6430615 | 0.80 | LCK (0.82) | LCKSRCTEKBTKKDR | |
| SCHEMBL6430619 | 0.80 | LCK (0.82) | LCKSRCTEKBTKKDR | |
| SCHEMBL5819558 | 0.80 | LCK (0.56) | LCKSRCTEKBTKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385524-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2006-02-01 | — | — | EP | disclosed |
| EP-1385524-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | Abbott GmbH & Co. KG (DE) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002080926-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-17 | — | — | WO | disclosed |