Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 10/20 | 0.62 |
| ▸ | HASPIN | Q8TF76 | 9/20 | 0.62 |
| ▸ | FLT3 | P36888 | 4/20 | 0.62 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29695173 | 1.00 | KCNH2 (0.62) | KCNH2HASPINFLT3CYP2C8CYP2C9 | |
| SCHEMBL23244781 | 0.88 | KCNH2 (0.61) | KCNH2HASPINFLT3CYP2C8CYP2C9 | |
| SCHEMBL29695157 | 0.88 | KCNH2 (0.61) | KCNH2HASPINFLT3CYP2C8CYP2C9 | |
| SCHEMBL29695183 | 0.88 | KCNH2 (0.65) | KCNH2HASPINFLT3CYP2C8CYP2C9 | |
| SCHEMBL23244918 | 0.88 | KCNH2 (0.65) | KCNH2HASPINFLT3CYP2C8CYP2C9 | |
| SCHEMBL23288684 | 0.81 | KCNH2 (0.63) | KCNH2HASPINFLT3CYP2C8CYP2C9 | |
| SCHEMBL23288608 | 0.80 | KCNH2 (0.68) | KCNH2HASPINFLT3CYP2C8CYP2C9 | |
| SCHEMBL29806017 | 0.80 | KCNH2 (0.63) | KCNH2HASPINFLT3CYP2C8CYP2C9 | |
| SCHEMBL23244868 | 0.80 | KCNH2 (0.63) | KCNH2HASPINFLT3CYP2C8CYP2C9 | |
| SCHEMBL23244905 | 0.80 | KCNH2 (0.65) | KCNH2HASPINFLT3CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11597733-B2 | Compounds and compositions for the treatment of parasitic diseases | NOVARTIS AG (CH) | 2023-03-07 | — | — | US | claimed |
| US-20210115065-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES | NOVARTIS AG (CH) | 2021-04-22 | — | — | US | claimed |
| US-11597733-B2 | Compounds and compositions for the treatment of parasitic diseases | NOVARTIS AG (CH) | 2023-03-07 | — | — | US | disclosed |
| US-20210115065-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES | NOVARTIS AG (CH) | 2021-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11597733-B2 | Compounds and compositions for the treatment of parasitic diseases | ABCB11, SQLE, FURIN | KCNH2 434/4885HASPIN 1610/4885FLT3 842/4885 |
| US-20210115065-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES | ABCB11, SQLE, FURIN | KCNH2 434/4885HASPIN 1610/4885FLT3 842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.