Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 3/20 | 0.45 |
| ▸ | BRD4 | O60885 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23247251 | 0.84 | L3MBTL1 (0.58) | L3MBTL1PTPN11HTR6BRD4LMNA | |
| SCHEMBL23247911 | 0.81 | PTPN11 (0.46) | L3MBTL1PTPN11LMNAALDH1A1MAPT | |
| SCHEMBL4166790 | 0.81 | PTPN11 (0.52) | L3MBTL1PTPN11BRD4LMNAALDH1A1 | |
| SCHEMBL4171120 | 0.81 | PTPN11 (0.75) | L3MBTL1PTPN11BRD4 | |
| SCHEMBL23247658 | 0.80 | PTPN11 (0.43) | L3MBTL1PTPN11HTR6BRD4SMN1; SMN2 | |
| SCHEMBL23248036 | 0.80 | PTPN11 (0.39) | L3MBTL1PTPN11HTR6BRD4MAPT | |
| SCHEMBL23247722 | 0.79 | PTPN11 (0.42) | L3MBTL1PTPN11HTR6BRD4SMN1; SMN2 | |
| SCHEMBL8944259 | 0.78 | L3MBTL1 (0.67) | L3MBTL1PTPN11HTR6LMNAALDH1A1 | |
| SCHEMBL23248021 | 0.78 | PTPN11 (0.43) | PTPN11 | |
| SCHEMBL4159580 | 0.78 | PTPN11 (0.56) | L3MBTL1PTPN11HTR6BRD4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021074279-A1 | SPIRO-FUSED TRICYCLIC MAP4K1 INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2021-04-22 | — | — | WO | disclosed |