Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 12/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.38 |
| ▸ | YAP1 | P46937 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23252394 | 0.78 | HRH3 (0.42) | MCHR1HRH3ENPP2YAP1 | |
| SCHEMBL118275 | 0.75 | ENPP2 (0.45) | MCHR1HRH3ENPP2 | |
| SCHEMBL116941 | 0.73 | MCHR1 (0.42) | MCHR1ENPP2 | |
| SCHEMBL2806616 | 0.73 | MCHR1 (0.41) | MCHR1ENPP2 | |
| SCHEMBL16927741 | 0.71 | MCHR1 (0.42) | MCHR1ENPP2 | |
| SCHEMBL23252435 | 0.71 | ENPP2 (0.43) | MCHR1HRH3ENPP2YAP1EPHX2 | |
| SCHEMBL117453 | 0.70 | HRH3 (0.43) | HRH3ENPP2 | |
| SCHEMBL117412 | 0.70 | HRH3 (0.43) | HRH3ENPP2 | |
| SCHEMBL2812353 | 0.70 | ENPP2 (0.40) | MCHR1HRH3ENPP2 | |
| SCHEMBL16252471 | 0.69 | ENPP2 (0.47) | MCHR1ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2623101-B1 | Piperidine and piperazine derivatives as autotaxin inhibitors | MERCK PATENT GMBH (DE) | 2021-04-21 | — | — | EP | disclosed |