Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 4/20 | 0.68 |
| ▸ | COMT | P21964 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23254889 | 0.96 | COMT (0.67) | FTOCOMTKMT2AGAAALDH1A1 | |
| SCHEMBL24386438 | 0.89 | FTO (0.54) | FTOCOMTKMT2AGAAALDH1A1 | |
| SCHEMBL23255166 | 0.88 | FTO (0.53) | FTOCOMTKMT2AGAAALDH1A1 | |
| SCHEMBL24386463 | 0.86 | COMT (0.53) | FTOCOMTKMT2AGAAALDH1A1 | |
| SCHEMBL24386389 | 0.83 | FTO (0.65) | FTOCOMTKMT2AGAAALDH1A1 | |
| SCHEMBL24386531 | 0.82 | COMT (0.56) | FTOCOMTKMT2AGAAALDH1A1 | |
| SCHEMBL29493687 | 0.81 | FTO (1.00) | FTOCOMT | |
| SCHEMBL29493670 | 0.81 | FTO (1.00) | FTOCOMT | |
| SCHEMBL20100869 | 0.81 | FTO (1.00) | FTOCOMT | |
| SCHEMBL28717335 | 0.81 | FTO (1.00) | FTOCOMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3885337-A1 | FTO INHIBITORS | National Institute Of Biological Sciences, Beijing (CN) | 2021-09-29 | — | — | EP | disclosed |
| EP-3303283-B1 | FTO INHIBITORS | NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN) | 2021-04-21 | — | — | EP | disclosed |