Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.67 |
| ▸ | MEN1 | O00255 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.66 |
| ▸ | COMT | P21964 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 3/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | NEK2 | P51955 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23255056 | 0.99 | FTO (0.68) | KMT2AMEN1ALDH1A1GAAKDM4E | |
| SCHEMBL23254885 | 0.97 | COMT (0.67) | KMT2AMEN1ALDH1A1GAAKDM4E | |
| SCHEMBL23255168 | 0.95 | EGFR (0.65) | KMT2AMEN1ALDH1A1GAAKDM4E | |
| SCHEMBL23254887 | 0.86 | FTO (0.55) | KMT2AMEN1ALDH1A1GAAKDM4E | |
| SCHEMBL18292294 | 0.80 | KMT2A (1.00) | KMT2AMEN1ALDH1A1GAAKDM4E | |
| SCHEMBL24386486 | 0.80 | COMT (0.65) | KMT2AMEN1ALDH1A1GAAKDM4E | |
| SCHEMBL29493654 | 0.80 | FTO (1.00) | KMT2AMEN1ALDH1A1GAAKDM4E | |
| SCHEMBL7997312 | 0.80 | FTO (1.00) | KMT2AMEN1ALDH1A1GAAKDM4E | |
| SCHEMBL29493659 | 0.80 | FTO (1.00) | KMT2AMEN1ALDH1A1GAAKDM4E | |
| SCHEMBL4375314 | 0.79 | KMT2A (0.97) | KMT2AMEN1ALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3503883-B1 | ENTACAPONE-RELATED COMPOUNDS TO TREAT MACULAR DEGENERATION | NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN) | 2022-05-04 | — | — | EP | disclosed |
| EP-3885337-A1 | FTO INHIBITORS | National Institute Of Biological Sciences, Beijing (CN) | 2021-09-29 | — | — | EP | disclosed |
| EP-3303283-B1 | FTO INHIBITORS | NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN) | 2021-04-21 | — | — | EP | disclosed |