SCHEMBL23258013

SCHEMBL23258013

CC[C@H](O)c1cc2cc(Cl)ccc2o1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.50
TSHR P16473 1/20 0.47
TAS1R3 Q7RTX0 1/20 0.46
TAS1R1 Q7RTX1 1/20 0.46
MAOB P27338 3/20 0.45
KDM4E B2RXH2 4/20 0.43
GPR35 Q9HC97 2/20 0.43
ALDH1A1 P00352 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2C9 P11712 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.41
HSD17B10 Q99714 1/20 0.41
CYP19A1 P11511 1/20 0.40
HRH4 Q9H3N8 1/20 0.40
KMT2A Q03164 2/20 0.39
MEN1 O00255 1/20 0.39
POLB P06746 1/20 0.39
CYP2D6 P10635 1/20 0.39
HIF1A Q16665 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23257824 0.87 CA12 (0.45) ALOX5TSHRTAS1R3TAS1R1CYP19A1
SCHEMBL10962574 0.87 ALOX5 (0.50) ALOX5TSHRTAS1R3TAS1R1MAOB
SCHEMBL17996583 0.83 ALOX5 (0.50) ALOX5TSHRTAS1R3TAS1R1MAOB
SCHEMBL24174705 0.80 CYP2D6 (0.39) TAS1R3TAS1R1MAOBCYP2D6HIF1A
SCHEMBL24681203 0.80 ALOX5 (0.47) ALOX5TSHRTAS1R3TAS1R1MAOB
SCHEMBL23257937 0.78 CYP2D6 (0.38) ALOX5TAS1R3TAS1R1ALDH1A1CYP2D6
SCHEMBL29172969 0.77 CYP2D6 (0.60) TAS1R3TAS1R1MAOBKDM4EALDH1A1
SCHEMBL24173635 0.77 CYP2D6 (0.60) TAS1R3TAS1R1MAOBKDM4EALDH1A1
SCHEMBL12248487 0.77 ALOX5 (0.56) ALOX5TSHRMAOBKDM4EGPR35
SCHEMBL17996587 0.76 ALOX5 (0.50) ALOX5TSHRTAS1R3TAS1R1MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022079092-A1 TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2022-04-21 WO disclosed
WO-2022002780-A1 TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2022-01-06 WO disclosed
WO-2021074197-A1 THIENOPYRIMIDONES AS TRPA1 INHIBITORS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2021-04-22 WO disclosed