Sugi Predict

Sugi Predict / Compounds / SCHEMBL23258366

SCHEMBL23258366

SCHEMBL23258366

Cc1cc(NCCN)nc(NC(=O)Nc2ccc(F)c(C(F)(F)F)c2)n1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 1/20 0.47
▸ TSHR P16473 1/20 0.47
▸ AR P10275 1/20 0.47
▸ STK17A Q9UEE5 2/20 0.46
▸ CDK8 P49336 2/20 0.45
▸ SMN1; SMN2 Q16637 2/20 0.44
▸ KDR P35968 7/20 0.43
▸ KIT P10721 2/20 0.43
▸ FLT3 P36888 2/20 0.43
▸ ABL1 P00519 1/20 0.43
▸ LCK P06239 1/20 0.43
▸ CSF1R P07333 1/20 0.43
▸ LYN P07948 1/20 0.43
▸ SRC P12931 1/20 0.43
▸ FLT1 P17948 1/20 0.43
▸ FLT4 P35916 1/20 0.43
▸ BLK P51451 1/20 0.43
▸ KMT2A Q03164 2/20 0.43
▸ NPC1 O15118 1/20 0.43
▸ POLB P06746 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23258604 0.95 STK17A (0.52) ALDH1A1TSHRARSTK17ACDK8
SCHEMBL23258606 0.94 STK17A (0.48) ALDH1A1TSHRARSTK17ACDK8
SCHEMBL18037978 0.92 ALDH1A1 (0.47) ALDH1A1TSHRARSTK17ACDK8
SCHEMBL23259063 0.92 ALDH1A1 (0.47) ALDH1A1TSHRARSTK17ACDK8
SCHEMBL23258626 0.91 ALDH1A1 (0.44) ALDH1A1TSHRARSTK17ACDK8
SCHEMBL18038081 0.90 ALDH1A1 (0.45) ALDH1A1TSHRARSTK17ACDK8
SCHEMBL23258570 0.90 KDR (0.55) ALDH1A1TSHRCDK8KDRFLT3
SCHEMBL23258965 0.90 ALDH1A1 (0.48) ALDH1A1TSHRARCDK8SMN1; SMN2
SCHEMBL23258603 0.89 ALDH1A1 (0.44) ALDH1A1TSHRARSTK17ACDK8
SCHEMBL23258206 0.89 ALDH1A1 (0.44) ALDH1A1TSHRARSTK17ACDK8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230271926-A1 INHIBITION OF OLIG2 ACTIVITY Curtana Pharmaceuticals, Inc. 2023-08-31 — — US disclosed
US-20230271926-A1 INHIBITION OF OLIG2 ACTIVITY Curtana Pharmaceuticals, Inc. 2023-08-31 — — US disclosed
US-11691951-B2 Inhibition of Olig2 activity Curtana Pharmaceuticals, Inc. (US) 2023-07-04 — — US disclosed
US-11691951-B2 Inhibition of Olig2 activity Curtana Pharmaceuticals, Inc. (US) 2023-07-04 — — US disclosed
US-20210347739-A1 INHIBITION OF OLIG2 ACTIVITY Curtana Pharmaceuticals, Inc. 2021-11-11 — — US disclosed
US-20210114991-A1 INHIBITION OF OLIG2 ACTIVITY Curtana Pharmaceuticals, Inc. 2021-04-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210114991-A1 INHIBITION OF OLIG2 ACTIVITY GLI2, ING2, GMFG ALDH1A1 1478/4885TSHR 4810/4885AR 3964/4885
US-11691951-B2 Inhibition of Olig2 activity GLI2, ING2, GMFG ALDH1A1 1478/4885TSHR 4810/4885AR 3964/4885
US-20210347739-A1 INHIBITION OF OLIG2 ACTIVITY GLI2, ING2, GMFG ALDH1A1 1478/4885TSHR 4810/4885AR 3964/4885
US-20230271926-A1 INHIBITION OF OLIG2 ACTIVITY GLI2, ING2, GMFG ALDH1A1 1478/4885TSHR 4810/4885AR 3964/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.