Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CES2 | O00748 | 2/20 | 0.32 |
| ▸ | CES1 | P23141 | 2/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALB | P02768 | 1/20 | 0.30 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23258769 | 0.81 | ELANE (0.40) | ELANEKMT2AALDH1A1SMN1; SMN2SCN5A | |
| SCHEMBL23258470 | 0.80 | ELANE (0.39) | ELANEKMT2AALDH1A1MAPTSCN5A | |
| SCHEMBL23263316 | 0.78 | CTPS1 (0.32) | — | |
| SCHEMBL23258467 | 0.77 | SCN5A (0.40) | ELANESCN5ASCN9A | |
| SCHEMBL7861711 | 0.73 | KDM4E (0.46) | ELANEKMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL23258557 | 0.72 | ELANE (0.37) | ELANEALDH1A1CES2CES1MAPT | |
| SCHEMBL23258688 | 0.71 | MAOA (0.35) | ELANEMAPTSMN1; SMN2SCN9ANPC1 | |
| SCHEMBL28710539 | 0.70 | KMT2A (0.41) | KMT2AALDH1A1CES2CES1BCHE | |
| SCHEMBL23259172 | 0.69 | ELANE (0.31) | ELANEKMT2AMEN1 | |
| SCHEMBL23263208 | 0.69 | ELANE (0.37) | ELANEKMT2ASCN5ASCN9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021076938-A1 | TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS | Ambys Medicines, Inc. (US) | 2021-04-22 | — | — | WO | disclosed |