Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.65 |
| ▸ | MST1R | Q04912 | 4/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2326086 | 0.89 | MET (0.60) | METMST1RKCNH2 | |
| SCHEMBL2326915 | 0.88 | MET (0.65) | METMST1RKCNH2 | |
| SCHEMBL2326081 | 0.87 | MET (0.57) | METMST1RKCNH2 | |
| SCHEMBL2322239 | 0.84 | MET (0.74) | METMST1RKCNH2 | |
| SCHEMBL2325791 | 0.83 | MET (0.42) | METMST1R | |
| SCHEMBL2323866 | 0.81 | MET (0.78) | METMST1RKCNH2 | |
| SCHEMBL2326812 | 0.81 | MET (0.78) | METMST1RKCNH2 | |
| SCHEMBL2444024 | 0.80 | MET (0.83) | METMST1RKCNH2 | |
| SCHEMBL2444637 | 0.78 | MET (0.74) | METMST1RKCNH2 | |
| SCHEMBL2444634 | 0.78 | MET (0.74) | METMST1RKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896421-B1 | BENZOCYCLOHEPTAPYRIDINES AS INHIBITORS OF THE RECEPTOR TYROSINE KINASE MET | MERCK SHARP & DOHME (US) | 2011-09-14 | — | — | EP | claimed |
| EP-1896422-B1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2011-08-17 | — | — | EP | claimed |