Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 3/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | TYR | P14679 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MDM4 | O15151 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | CA5A | P35218 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23258683 | 0.83 | HDAC4 (0.60) | HDAC4HDAC8TP53ALOX12HDAC2 | |
| SCHEMBL13905659 | 0.77 | HDAC4 (0.57) | HDAC4HDAC8TP53ALOX12HDAC2 | |
| SCHEMBL729860 | 0.76 | HDAC4 (0.52) | HDAC4HDAC8TP53ALOX12HDAC2 | |
| SCHEMBL19509164 | 0.75 | HDAC4 (0.55) | HDAC4HDAC8TP53ALOX12HDAC2 | |
| SCHEMBL23893050 | 0.75 | HDAC4 (0.55) | HDAC4HDAC8TP53ALOX12HDAC2 | |
| Hinokitiol SCHEMBL158795 | 0.75 | TYR (0.71) | HDAC4HDAC8TP53ALOX12HDAC2 | |
| SCHEMBL374780 | 0.74 | HDAC4 (0.56) | HDAC4HDAC8TP53ALOX12HDAC2 | |
| Hinokitiol SCHEMBL29375027 | 0.73 | HDAC4 (0.58) | HDAC4HDAC8TP53ALOX12HDAC2 | |
| Hinokitiol SCHEMBL27478967 | 0.73 | TYR (0.69) | HDAC4HDAC8TP53ALOX12HDAC2 | |
| Hinokitiol SCHEMBL27495431 | 0.73 | TYR (0.69) | HDAC4HDAC8TP53ALOX12HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021076938-A1 | TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS | Ambys Medicines, Inc. (US) | 2021-04-22 | — | — | WO | disclosed |