Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | NQO1 | P15559 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23258511 | 0.83 | ELANE (0.50) | ELANEKMT2ALMNATDP1PARP10 | |
| SCHEMBL23258827 | 0.80 | ELANE (0.45) | ELANEKMT2AMEN1LMNATDP1 | |
| SCHEMBL23258874 | 0.80 | ELANE (0.45) | ELANEKMT2AMEN1LMNATDP1 | |
| SCHEMBL23258611 | 0.79 | ELANE (0.46) | ELANEKMT2AMEN1LMNAPARP10 | |
| SCHEMBL23258561 | 0.78 | ELANE (0.44) | ELANEKMT2AMEN1MAPTNPC1 | |
| SCHEMBL27018128 | 0.78 | ELANE (0.44) | ELANEKMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL23249891 | 0.78 | ELANE (0.44) | ELANEKMT2AMEN1LMNACYP1A2 | |
| SCHEMBL27018499 | 0.76 | TYR (0.43) | ELANEKMT2AMEN1MAPTNPC1 | |
| SCHEMBL23258463 | 0.75 | ELANE (0.42) | ELANELMNAPARP10MAPTALDH1A1 | |
| SCHEMBL27018501 | 0.75 | ELANE (0.47) | ELANEKMT2ACYP1A2TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021076938-A1 | TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS | Ambys Medicines, Inc. (US) | 2021-04-22 | — | — | WO | disclosed |