Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | KIF5B | P33176 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29677789 | 0.84 | HTT (0.50) | HTTNPC1TSHRGLASMN1; SMN2 | |
| SCHEMBL282059 | 0.84 | HTT (0.50) | HTTNPC1TSHRGLASMN1; SMN2 | |
| SCHEMBL7108662 | 0.82 | HTT (0.48) | HTTNPC1TSHRGLASMN1; SMN2 | |
| SCHEMBL23259190 | 0.80 | HSP90AA1 (0.56) | GAAHTTTSHRGLASMN1; SMN2 | |
| SCHEMBL19509694 | 0.77 | ALDH1A1 (0.45) | GAAHTTTSHRGLASMN1; SMN2 | |
| SCHEMBL265537 | 0.75 | KDM4E (0.42) | HTTNPC1TDP1LMNAEGFR | |
| SCHEMBL17070605 | 0.75 | KDM4E (0.42) | HTTNPC1TDP1LMNAEGFR | |
| SCHEMBL29365368 | 0.75 | KDM4E (0.42) | HTTNPC1TDP1LMNAEGFR | |
| SCHEMBL23259189 | 0.74 | KDM4E (0.43) | HTTALDH1A1LMNAMAPK1 | |
| SCHEMBL7110169 | 0.74 | KDM4E (0.41) | HTTNPC1TDP1LMNAEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021076938-A1 | TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS | Ambys Medicines, Inc. (US) | 2021-04-22 | — | — | WO | disclosed |