Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 14/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.45 |
| ▸ | MERTK | Q12866 | 1/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2321132 | 0.89 | PLK1 (0.44) | PLK1BRD4BRDTTYRO3TTK | |
| SCHEMBL2323774 | 0.88 | TYRO3 (0.45) | PLK1BRD4BRDTTYRO3TTK | |
| SCHEMBL2325615 | 0.87 | PLK1 (0.45) | PLK1BRD4BRDTTTKKMT2A | |
| SCHEMBL2323716 | 0.86 | PLK1 (0.47) | PLK1BRD4BRDTIKBKBABL1 | |
| SCHEMBL2325894 | 0.86 | PLK1 (0.46) | PLK1BRD4BRDTMERTKTTK | |
| SCHEMBL2325152 | 0.86 | PLK1 (0.44) | PLK1BRD4BRDTTTK | |
| SCHEMBL2325432 | 0.86 | PLK1 (0.44) | PLK1BRD4BRDTTTK | |
| SCHEMBL2321921 | 0.86 | PLK1 (0.45) | PLK1BRD4BRDTTYRO3TTK | |
| SCHEMBL2324931 | 0.85 | PLK1 (0.45) | PLK1BRD4BRDTTYRO3MERTK | |
| SCHEMBL2326310 | 0.84 | PLK1 (0.43) | PLK1BRD4BRDTTTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356122-A1 | PROTEIN KINASE INHIBITORS | Vertex Pharmceuticals Incorporated (US) | 2011-08-17 | — | — | EP | claimed |
| WO-2010008454-A1 | PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-01-21 | — | — | WO | claimed |