SCHEMBL23267093

SCHEMBL23267093

CNC(=O)COc1cc2cc(Nc3nc(N4CCOCC4)ncc3Cl)ccc2n(C(C)C)c1=O

nearest known ligand 0.64

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ BCL6 P41182 17/20 0.64
▸ NCOR2 Q9Y618 6/20 0.64
▸ MELK Q14680 1/20 0.62
▸ CHRM4 P08173 1/20 0.51
▸ BCL6B Q8N143 1/20 0.51
▸ SYK P43405 1/20 0.44
▸ ALK Q9UM73 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23267504 0.93 BCL6 (0.65) BCL6NCOR2MELKCHRM4BCL6B
SCHEMBL23267505 0.93 BCL6 (0.65) BCL6NCOR2MELKCHRM4BCL6B
SCHEMBL23267037 0.92 BCL6 (0.64) BCL6NCOR2MELKCHRM4BCL6B
SCHEMBL20284384 0.92 BCL6 (0.65) BCL6NCOR2MELKCHRM4BCL6B
SCHEMBL23267149 0.92 BCL6 (0.65) BCL6NCOR2MELKCHRM4BCL6B
SCHEMBL29333173 0.91 BCL6 (0.62) BCL6NCOR2MELKCHRM4BCL6B
SCHEMBL23267750 0.91 BCL6 (0.64) BCL6NCOR2MELKCHRM4BCL6B
SCHEMBL23267153 0.90 BCL6 (0.68) BCL6NCOR2MELKCHRM4BCL6B
SCHEMBL20284555 0.90 BCL6 (0.66) BCL6NCOR2MELKCHRM4BCL6B
SCHEMBL20284080 0.90 BCL6 (0.78) BCL6NCOR2MELKCHRM4BCL6B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021077010-A1 BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY ARVINAS OPERATIONS, INC. (US) 2021-04-22 — — WO disclosed
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