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SCHEMBL23267395

SCHEMBL23267395

CNC(=O)COc1cc2cc(Nc3nc(N4CCC5(CC4)CC(OC4CCN(c6ccc7c(c6)C(=O)N(C6CCC(=O)NC6=O)C7=O)CC4)C5)ncc3Cl)ccc2n(C(C)C)c1=O

nearest known ligand 0.48

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ BCL6 P41182 7/20 0.48
▸ NCOR2 Q9Y618 4/20 0.48
▸ MELK Q14680 1/20 0.47
▸ EGFR P00533 11/20 0.44
▸ ERBB2 P04626 2/20 0.44
▸ PTK2 Q05397 1/20 0.44
▸ ERBB3 P21860 2/20 0.43
▸ CHRM4 P08173 1/20 0.41
▸ BCL6B Q8N143 1/20 0.41
▸ ALK Q9UM73 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23267398 1.00 BCL6 (0.48) BCL6NCOR2MELKEGFRERBB2
SCHEMBL23267932 0.96 BCL6 (0.52) BCL6NCOR2MELKEGFRERBB2
SCHEMBL31595358 0.95 BCL6 (0.48) BCL6NCOR2MELKEGFRERBB2
SCHEMBL24718779 0.94 BCL6 (0.47) BCL6NCOR2MELKEGFRERBB2
SCHEMBL30894324 0.94 BCL6 (0.47) BCL6NCOR2MELKEGFRERBB2
SCHEMBL30894407 0.94 BCL6 (0.46) BCL6NCOR2MELKEGFRERBB2
SCHEMBL24718138 0.94 BCL6 (0.46) BCL6NCOR2MELKEGFRERBB2
SCHEMBL30798264 0.94 BCL6 (0.46) BCL6NCOR2MELKEGFRERBB2
SCHEMBL23250106 0.93 BCL6 (0.48) BCL6NCOR2MELKEGFRERBB2
SCHEMBL23267983 0.93 BCL6 (0.48) BCL6NCOR2MELKEGFRERBB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021077010-A1 BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY ARVINAS OPERATIONS, INC. (US) 2021-04-22 — — WO disclosed
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