SCHEMBL23267461

SCHEMBL23267461

CNC(=O)COc1cc2cc(Nc3nc(N4CCN(C(C)C)CC4)ncc3Cl)ccc2n(C)c1=O

nearest known ligand 0.74

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ BCL6 P41182 20/20 0.74
▸ MELK Q14680 1/20 0.74
▸ NCOR2 Q9Y618 5/20 0.73
▸ CHRM4 P08173 1/20 0.56
▸ BCL6B Q8N143 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24717536 0.92 BCL6 (0.79) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL24717331 0.91 BCL6 (0.80) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL23267531 0.91 BCL6 (0.76) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL20284551 0.91 BCL6 (0.79) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL23267186 0.91 BCL6 (0.79) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL23267679 0.89 BCL6 (0.76) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL23267191 0.89 BCL6 (0.74) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL20284365 0.89 BCL6 (0.74) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL20284194 0.89 BCL6 (0.80) BCL6MELKNCOR2CHRM4BCL6B
SCHEMBL23267064 0.89 BCL6 (0.78) BCL6MELKNCOR2CHRM4BCL6B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021077010-A1 BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY ARVINAS OPERATIONS, INC. (US) 2021-04-22 — — WO disclosed
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