Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL6 | P41182 | 20/20 | 0.76 |
| ▸ | MELK | Q14680 | 1/20 | 0.76 |
| ▸ | NCOR2 | Q9Y618 | 7/20 | 0.75 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.58 |
| ▸ | BCL6B | Q8N143 | 1/20 | 0.58 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23267606 | 0.97 | BCL6 (0.72) | BCL6MELKNCOR2CHRM4BCL6B | |
| SCHEMBL24717536 | 0.94 | BCL6 (0.79) | BCL6MELKNCOR2CHRM4BCL6B | |
| SCHEMBL23267499 | 0.93 | BCL6 (0.66) | BCL6MELKNCOR2CHRM4BCL6B | |
| SCHEMBL24717331 | 0.93 | BCL6 (0.80) | BCL6MELKNCOR2CHRM4BCL6B | |
| SCHEMBL23267184 | 0.92 | BCL6 (0.65) | BCL6MELKNCOR2CHRM4BCL6B | |
| SCHEMBL23267186 | 0.92 | BCL6 (0.79) | BCL6MELKNCOR2CHRM4BCL6B | |
| SCHEMBL20284551 | 0.92 | BCL6 (0.79) | BCL6MELKNCOR2CHRM4BCL6B | |
| SCHEMBL23267204 | 0.91 | BCL6 (0.64) | BCL6MELKNCOR2CHRM4BCL6B | |
| SCHEMBL23267461 | 0.91 | BCL6 (0.74) | BCL6MELKNCOR2CHRM4BCL6B | |
| SCHEMBL23267191 | 0.91 | BCL6 (0.74) | BCL6MELKNCOR2CHRM4BCL6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024151557-A1 | MODULATORS OF BCL6 PROTEOLYSIS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-07-18 | — | — | WO | disclosed |
| WO-2021077010-A1 | BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY | ARVINAS OPERATIONS, INC. (US) | 2021-04-22 | — | — | WO | disclosed |