Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18330456 | 0.86 | ALDH1A1 (0.56) | ALDH1A1NPC1TSHRHPGDKDM4E | |
| SCHEMBL25581265 | 0.83 | ALDH1A1 (0.42) | ALDH1A1NPC1TSHRHPGDL3MBTL1 | |
| SCHEMBL27456239 | 0.83 | NPC1 (0.59) | ALDH1A1NPC1TSHRHPGDMEN1 | |
| SCHEMBL15040863 | 0.82 | MEN1 (0.55) | ALDH1A1NPC1HPGDMEN1KMT2A | |
| SCHEMBL7706487 | 0.78 | ALDH1A1 (0.60) | ALDH1A1NPC1TSHRHPGDKDM4E | |
| SCHEMBL19703776 | 0.77 | ALDH1A1 (0.58) | ALDH1A1NPC1TSHRHPGDKDM4E | |
| SCHEMBL25934419 | 0.77 | ALDH1A1 (0.58) | ALDH1A1NPC1TSHRHPGDKDM4E | |
| SCHEMBL21477198 | 0.76 | NPC1 (0.46) | ALDH1A1NPC1TSHRHPGDKDM4E | |
| SCHEMBL12410266 | 0.76 | NPC1 (0.62) | ALDH1A1NPC1HPGDKDM4EMEN1 | |
| SCHEMBL10274470 | 0.76 | NPC1 (0.74) | ALDH1A1NPC1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024020221-A1 | MODULATORS OF TYK2 PROTEOLYSIS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2024-01-25 | — | — | WO | disclosed |
| WO-2021194878-A1 | SELECTIVE MODULATORS OF MUTANT LRRK2 PROTEOLYSIS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2021-09-30 | — | — | WO | disclosed |
| WO-2021077010-A1 | BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY | ARVINAS OPERATIONS, INC. (US) | 2021-04-22 | — | — | WO | disclosed |