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SCHEMBL23267940

SCHEMBL23267940

CCn1c(=O)c(OCC(=O)NC)cc2cc(Nc3nc(N4CCC(CN5CCC(c6ccc7c(c6)C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CC4)ncc3Cl)ccc21

nearest known ligand 0.50

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ BTK Q06187 2/20 0.50
▸ BCL6 P41182 9/20 0.49
▸ NCOR2 Q9Y618 4/20 0.49
▸ MELK Q14680 1/20 0.48
▸ ALK Q9UM73 5/20 0.43
▸ PTK2 Q05397 1/20 0.42
▸ CHRM4 P08173 1/20 0.41
▸ BCL6B Q8N143 1/20 0.41
▸ CRBN Q96SW2 4/20 0.40
▸ AR P10275 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29874234 0.95 BCL6 (0.56) BTKBCL6NCOR2MELKALK
SCHEMBL23249932 0.95 BCL6 (0.56) BTKBCL6NCOR2MELKALK
SCHEMBL23266265 0.93 BCL6 (0.49) BTKBCL6NCOR2MELKALK
SCHEMBL31595571 0.93 BCL6 (0.49) BTKBCL6NCOR2MELKALK
SCHEMBL23267945 0.93 BTK (0.49) BTKBCL6NCOR2MELKALK
SCHEMBL31595200 0.91 BCL6 (0.48) BTKBCL6NCOR2MELKALK
SCHEMBL23267924 0.91 BCL6 (0.49) BTKBCL6NCOR2MELKALK
SCHEMBL30798538 0.89 BCL6 (0.47) BTKBCL6NCOR2MELKALK
SCHEMBL24717637 0.89 BCL6 (0.47) BTKBCL6NCOR2MELKALK
SCHEMBL30798354 0.89 BCL6 (0.47) BTKBCL6NCOR2MELKALK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021077010-A1 BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY ARVINAS OPERATIONS, INC. (US) 2021-04-22 — — WO disclosed
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