Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 11/20 | 0.37 |
| ▸ | LCK | P06239 | 10/20 | 0.37 |
| ▸ | TEK | Q02763 | 9/20 | 0.37 |
| ▸ | KDR | P35968 | 4/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 3/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2325503 | 1.00 | SRC (0.37) | SRCLCKTEKKDRLIMK1 | |
| SCHEMBL2326487 | 0.96 | SRC (0.38) | SRCLCKTEKKDRLIMK1 | |
| SCHEMBL2324968 | 0.96 | SRC (0.38) | SRCLCKTEKKDRLIMK1 | |
| SCHEMBL15482407 | 0.85 | HTT (0.32) | HTT | |
| SCHEMBL2324317 | 0.84 | TLR9 (0.31) | TLR9TLR7TLR8HTT | |
| SCHEMBL2323449 | 0.84 | CDK9 (0.39) | TLR9TLR7TLR8 | |
| SCHEMBL2323235 | 0.84 | TLR9 (0.32) | TLR9TLR7TLR8 | |
| SCHEMBL2325192 | 0.84 | TLR9 (0.38) | SRCLCKKDRABL1TLR9 | |
| SCHEMBL2324337 | 0.83 | TLR9 (0.36) | SRCLCKKDRABL1TLR9 | |
| SCHEMBL2324198 | 0.82 | HTT (0.33) | LCKKDRABL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2534151-A1 | 8-METHYL-1-PHENYL-IMIDAZOL[1,5-A]PYRAZINE COMPOUNDS | MSD Oss B.V. (NL) | 2012-12-19 | — | — | EP | disclosed |
| WO-2011095556-A1 | 8-METHYL-1-PHENYL-IMIDAZOL[1,5-A]PYRAZINE COMPOUNDS | N.V. ORGANON (NL) | 2011-08-11 | — | — | WO | disclosed |