Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 9/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | KIF18A | Q8NI77 | 4/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29762439 | 1.00 | ADORA2A (0.43) | ADORA2AADORA1GAAKDM4EMEN1 | |
| SCHEMBL23299951 | 0.88 | KIF18A (0.48) | ADORA2AADORA1GAAKDM4EMEN1 | |
| SCHEMBL29762432 | 0.85 | ADORA2A (0.44) | ADORA2AADORA1GAAKDM4EMEN1 | |
| SCHEMBL23274660 | 0.85 | ADORA2A (0.44) | ADORA2AADORA1GAAKDM4EMEN1 | |
| SCHEMBL29762385 | 0.82 | ADORA2A (0.59) | ADORA2AADORA1GAAKDM4EMEN1 | |
| SCHEMBL23274769 | 0.82 | ADORA2A (0.59) | ADORA2AADORA1GAAKDM4EMEN1 | |
| SCHEMBL29762502 | 0.75 | KMT2A (0.43) | GAAKDM4EMEN1ALDH1A1THRB | |
| SCHEMBL23275325 | 0.75 | KMT2A (0.43) | GAAKDM4EMEN1ALDH1A1THRB | |
| SCHEMBL23299941 | 0.73 | HTT (0.45) | GAAKDM4EMEN1ALDH1A1THRB | |
| SCHEMBL23275349 | 0.72 | KIF18A (0.48) | PIK3CAPIK3CBKIF18A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12312336-B2 | Inhibitors of RAF kinases | Pierre Fabre Médicament (FR) | 2025-05-27 | — | — | US | disclosed |
| EP-4048259-A1 | INHIBITORS OF RAF KINASES | Kinnate Biopharma Inc. (US) | 2022-08-31 | — | — | EP | disclosed |
| CN-114845711-A | Inhibitors of RAF kinase | 金耐特生物制药公司 | 2022-08-02 | — | — | CN | disclosed |
| US-20210300904-A1 | INHIBITORS OF RAF KINASES | Pierre Fabre Médicament (FR) | 2021-09-30 | — | — | US | disclosed |
| US-20210300904-A1 | INHIBITORS OF RAF KINASES | Pierre Fabre Médicament (FR) | 2021-09-30 | — | — | US | disclosed |
| WO-2021081375-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2021-04-29 | — | — | WO | disclosed |
| WO-2021081375-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2021-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210300904-A1 | INHIBITORS OF RAF KINASES | BRAF, RAF1, ARAF | ADORA2A 3874/4885ADORA1 4378/4885GAA 1754/4885 |
| US-12312336-B2 | Inhibitors of RAF kinases | BRAF, RAF1, ARAF | ADORA2A 3874/4885ADORA1 4378/4885GAA 1754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.