Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GNE | Q9Y223 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | LYPLA2 | O95372 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23095872 | 0.85 | ALDH1A1 (0.40) | HPGDALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL19114768 | 0.78 | HPGD (0.36) | HPGDALDH1A1NPC1TSHRMEN1 | |
| SCHEMBL23048514 | 0.76 | GABRR1 (0.31) | — | |
| SCHEMBL1353549 | 0.76 | GABRR1 (0.31) | — | |
| SCHEMBL2535844 | 0.73 | HPGD (0.54) | HPGDALDH1A1HSD11B1TSHRLMNA | |
| SCHEMBL13726019 | 0.72 | PREP (0.32) | HPGDL3MBTL1 | |
| SCHEMBL2541166 | 0.71 | HPGD (0.50) | HPGDALDH1A1HSD11B1TSHRLMNA | |
| SCHEMBL2531710 | 0.69 | — | — | |
| SCHEMBL14003433 | 0.66 | HRH3 (0.43) | — | |
| SCHEMBL13620759 | 0.65 | GABRR1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189041-B1 | TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS | CTXT PTY LTD (AU) | 2021-04-28 | — | — | EP | disclosed |