Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
| ▸ | RELA | Q04206 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23280468 | 0.75 | — | — | |
| SCHEMBL28402044 | 0.69 | KMT2A (0.39) | TSHRKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL28402043 | 0.69 | KMT2A (0.39) | TSHRKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL28923707 | 0.69 | KMT2A (0.39) | TSHRKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL20920554 | 0.67 | — | — | |
| SCHEMBL28404479 | 0.66 | TSHR (0.42) | TSHRKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL28923579 | 0.66 | TSHR (0.42) | TSHRKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL28404480 | 0.66 | TSHR (0.42) | TSHRKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL24450636 | 0.65 | TDP1 (0.33) | KMT2A | |
| SCHEMBL6316661 | 0.64 | ALDH1A1 (0.42) | TSHRKDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189041-B1 | TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS | CTXT PTY LTD (AU) | 2021-04-28 | — | — | EP | disclosed |