Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 6/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.44 |
| ▸ | PRCP | P42785 | 1/20 | 0.43 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21794344 | 0.87 | PNMT (0.56) | PNMTADRA2AADRA2BADRA2CPRCP | |
| SCHEMBL21510095 | 0.85 | PNMT (0.57) | PNMTADRA2AADRA2BADRA2CPRCP | |
| SCHEMBL31158806 | 0.82 | PNMT (0.67) | PNMTADRA2AADRA2BADRA2CPRCP | |
| SCHEMBL13416396 | 0.82 | PNMT (0.67) | PNMTADRA2AADRA2BADRA2CPRCP | |
| SCHEMBL31158866 | 0.82 | PNMT (0.67) | PNMTADRA2AADRA2BADRA2CPRCP | |
| SCHEMBL12741563 | 0.82 | PNMT (0.67) | PNMTADRA2AADRA2BADRA2CPRCP | |
| SCHEMBL19853263 | 0.79 | PNMT (0.62) | PNMTADRA2AADRA2BADRA2CPRCP | |
| SCHEMBL13181686 | 0.79 | PNMT (0.62) | PNMTADRA2AADRA2BADRA2CPRCP | |
| SCHEMBL20759206 | 0.79 | PNMT (0.54) | PNMTADRA2AADRA2BADRA2CPRCP | |
| SCHEMBL24420061 | 0.78 | MEN1 (0.48) | PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189041-B1 | TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS | CTXT PTY LTD (AU) | 2021-04-28 | — | — | EP | disclosed |