Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 7/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.46 |
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.35 |
| ▸ | MYLK | Q15746 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13296776 | 0.86 | CYP11B2 (0.51) | CYP11B1CYP11B2GRM5PRMT5WDR77 | |
| SCHEMBL12093363 | 0.78 | CYP11B1 (0.50) | CYP11B1CYP11B2GRM5HCAR2 | |
| SCHEMBL17828132 | 0.78 | CYP11B2 (0.46) | CYP11B1CYP11B2GRM5POLBPRMT5 | |
| SCHEMBL10263371 | 0.77 | — | — | |
| SCHEMBL8477235 | 0.77 | CYP11B1 (0.57) | CYP11B1CYP11B2GRM5 | |
| SCHEMBL18387306 | 0.77 | CYP11B2 (0.45) | CYP11B1CYP11B2GRM5PRMT5WDR77 | |
| SCHEMBL26028133 | 0.77 | CYP11B2 (0.45) | CYP11B1CYP11B2GRM5PRMT5WDR77 | |
| SCHEMBL14300711 | 0.77 | CYP11B2 (0.45) | CYP11B1CYP11B2GRM5PRMT5WDR77 | |
| SCHEMBL16364018 | 0.77 | CYP11B2 (0.45) | CYP11B1CYP11B2GRM5PRMT5WDR77 | |
| SCHEMBL3706851 | 0.77 | CYP11B1 (0.45) | CYP11B1CYP11B2GRM5POLBPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023205769-A1 | A CHEMOSELECTIVE PHOTOCHEMICAL BIOCONJUGATION REACTION AND METHODS OF USE THEREOF | TRUSTEES OF BOSTON COLLEGE (US) | 2023-10-26 | — | — | WO | disclosed |
| EP-3189041-B1 | TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS | CTXT PTY LTD (AU) | 2021-04-28 | — | — | EP | disclosed |