Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 13/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23283135 | 0.82 | GRM5 (0.57) | GRM5PDGFRBPDGFRAAPP | |
| SCHEMBL1644262 | 0.75 | GRM5 (0.48) | GRM5PDGFRBPDGFRAGRM4APP | |
| SCHEMBL18479656 | 0.74 | APP (0.46) | GRM5GRM4APP | |
| SCHEMBL1644284 | 0.74 | MERTK (0.40) | GRM5 | |
| SCHEMBL1644286 | 0.74 | MERTK (0.40) | GRM5 | |
| SCHEMBL23283200 | 0.73 | EGLN1 (0.42) | GRM5APP | |
| SCHEMBL14840580 | 0.72 | GRM5 (1.00) | GRM5PDGFRBPDGFRAAPP | |
| SCHEMBL13388284 | 0.71 | FFAR1 (0.51) | GRM5GRM4 | |
| SCHEMBL12402642 | 0.70 | APP (0.64) | APP | |
| SCHEMBL14899146 | 0.67 | APP (0.40) | APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021080015-A1 | MODULATORS OF TREK (TWIK RELATED K+ CHANNELS) CHANNEL FUNCTION | ONO PHARMACEUTICAL CO., LTD. (JP) | 2021-04-29 | — | — | WO | disclosed |