Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 10/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21992215 | 0.84 | GRM5 (0.48) | APPFFAR1FFAR4GRM5GRM4 | |
| SCHEMBL22980536 | 0.74 | ALDH1A1 (0.47) | FFAR1FFAR4NPC1RAB9AMTOR | |
| SCHEMBL29666106 | 0.74 | ALDH1A1 (0.47) | FFAR1FFAR4NPC1RAB9AMTOR | |
| SCHEMBL23283151 | 0.74 | GRM5 (0.56) | APPGRM5GRM4 | |
| SCHEMBL16598714 | 0.74 | APP (0.52) | APPFFAR1FFAR4GRM4NPC1 | |
| SCHEMBL22980398 | 0.72 | KAT6A (0.45) | FFAR1FFAR4GRM4NPC1RAB9A | |
| SCHEMBL23010511 | 0.72 | GRM5 (0.39) | GRM5 | |
| SCHEMBL19354876 | 0.71 | TTR (0.37) | GRM5 | |
| SCHEMBL719199 | 0.71 | APP (0.55) | APPFFAR1FFAR4GRM5MAPT | |
| SCHEMBL22981705 | 0.71 | SLC22A12 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3331882-B1 | ETHYNYL DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2020-04-29 | — | — | EP | disclosed |
| WO-2017021384-A1 | ETHYNYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2017-02-09 | — | — | WO | disclosed |