Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 8/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.31 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2323238 | 0.85 | IKBKB (0.40) | IKBKBKDM4EPPARGNCOA2HSD17B10 | |
| SCHEMBL1704326 | 0.83 | IKBKB (0.36) | IKBKBKDM4EPPARGNCOA2HSD17B10 | |
| SCHEMBL2333861 | 0.80 | IKBKB (0.38) | IKBKBKDM4EPPARGNCOA2HSD17B10 | |
| SCHEMBL2331384 | 0.80 | IKBKB (0.38) | IKBKBKDM4EPPARGNCOA2HSD17B10 | |
| SCHEMBL2330806 | 0.78 | IKBKB (0.35) | IKBKBKDM4EPPARGNCOA2HSD17B10 | |
| SCHEMBL2327523 | 0.77 | IKBKB (0.41) | IKBKBKDM4EHSD17B10ALDH1A1RXRA | |
| SCHEMBL2329098 | 0.77 | MAPK14 (0.34) | IKBKBKDM4EHSD17B10TSHR | |
| SCHEMBL2328930 | 0.77 | HCRTR1 (0.44) | IKBKBSLC9A1NR4A2ADORA2AALDH1A1 | |
| SCHEMBL2327745 | 0.77 | IKBKB (0.39) | IKBKBKDM4EPPARGNCOA2HSD17B10 | |
| SCHEMBL2324582 | 0.77 | IKBKB (0.39) | IKBKBKDM4EPPARGNCOA2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | claimed |
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | disclosed |