Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 5/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TPH1 | P17752 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2323238 | 0.92 | IKBKB (0.40) | IKBKBHTTKDM4ETSHRHSD17B10 | |
| SCHEMBL2327523 | 0.91 | IKBKB (0.41) | IKBKBHTTKDM4EKMT2AHSD17B10 | |
| SCHEMBL2332690 | 0.90 | NR4A1 (0.37) | IKBKBKDM4EHSD17B10 | |
| SCHEMBL1704482 | 0.86 | MAPK14 (0.34) | MAPK14GRM2IKBKBKDM4E | |
| SCHEMBL2328930 | 0.85 | HCRTR1 (0.44) | IKBKBHTTTSHRKMT2A | |
| SCHEMBL2327731 | 0.85 | RXRA (0.41) | IKBKBHTTKDM4EKMT2A | |
| SCHEMBL2331266 | 0.84 | IKBKB (0.45) | IKBKBKDM4EKMT2A | |
| SCHEMBL2327590 | 0.84 | DGAT1 (0.37) | IKBKBHTTTPH1KDM4EUSP2 | |
| SCHEMBL2331664 | 0.83 | MAPK14 (0.34) | MAPK14IKBKB | |
| SCHEMBL2327470 | 0.83 | KCNK3 (0.34) | GRM2IKBKBMAPTHSD17B10HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | claimed |
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | disclosed |