SCHEMBL23285672

SCHEMBL23285672

C/C(=C\C=C(C#N)C#N)c1ccccc1OC(=O)c1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 1/20 0.54
KMT2A Q03164 8/20 0.44
MAPT P10636 3/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
HSD17B10 Q99714 4/20 0.43
KDM4E B2RXH2 3/20 0.43
LMNA P02545 2/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2C9 P11712 1/20 0.43
GAA P10253 2/20 0.42
ESR1 P03372 3/20 0.41
ALDH1A1 P00352 3/20 0.41
HPGD P15428 2/20 0.41
ITGB3 P05106 1/20 0.41
ITGA2B P08514 1/20 0.41
HMGB1 P09429 1/20 0.41
TSHR P16473 1/20 0.41
GGT1 P19440 1/20 0.41
PTGS1 P23219 1/20 0.41
PTGS2 P35354 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26490205 0.85 SLC6A3 (0.51) SLC6A3KMT2AMAPTSMN1; SMN2HSD17B10
SCHEMBL26091761 0.85 SLC6A3 (0.51) SLC6A3KMT2AMAPTSMN1; SMN2HSD17B10
SCHEMBL26490187 0.75 SLC6A3 (0.72) SLC6A3KMT2AMAPTSMN1; SMN2HSD17B10
SCHEMBL28691456 0.75 KMT2A (0.41) KMT2AMAPTKDM4ELMNACYP1A2
SCHEMBL11346276 0.72 SLC6A3 (0.68) SLC6A3KMT2AMAPTSMN1; SMN2HSD17B10
SCHEMBL30505635 0.71 SLC6A3 (0.71) SLC6A3KMT2AMAPTSMN1; SMN2HSD17B10
SCHEMBL1979275 0.71 SLC6A3 (0.71) SLC6A3KMT2AMAPTSMN1; SMN2HSD17B10
SCHEMBL113040 0.71 SLC6A3 (0.71) SLC6A3KMT2AMAPTSMN1; SMN2HSD17B10
Acetic Acid SCHEMBL29588064 0.71 KMT2A (0.68) SLC6A3KMT2AMAPTSMN1; SMN2HSD17B10
SCHEMBL11443998 0.71 SLC6A3 (0.60) SLC6A3KMT2AMAPTSMN1; SMN2HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021077194-A1 PROCESS FOR THE PRODUCTION OF ANTITUMOUR PHARMACEUTICAL COMPOSITIONS USING PUSH-PULL BUTADIENES, COMPOUNDS AND USES THEREOF ANHANGUERA EDUCACIONAL PARTICIPAÇÕES S/A (BR) 2021-04-29 WO disclosed