SCHEMBL23287986 — predicted protein targets

Predicted protein targets (top 16)

	gene	UniProt	supporting neighbours	confidence
▸	GRM5	P41594	2/20	0.38

▸	ACSS2	Q9NR19	1/20	0.36

▸	SYK	P43405	1/20	0.36

▸	S1PR3	Q99500	1/20	0.36

▸	RORC	P51449	3/20	0.35

▸	AGTR1	P30556	1/20	0.35

▸	AGTR2	P50052	1/20	0.35

▸	MAPKAPK2	P49137	2/20	0.34

▸	EGFR	P00533	1/20	0.34

▸	AURKB	Q96GD4	1/20	0.34

▸	MEN1	O00255	1/20	0.34

▸	LMNA	P02545	1/20	0.34

▸	KMT2A	Q03164	1/20	0.34

▸	SMN1; SMN2	Q16637	1/20	0.34

▸	PTPN11	Q06124	1/20	0.34

▸	GLS	O94925	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL27240244	0.78	GRM5 (0.42)	GRM5ACSS2SYKRORCMEN1
SCHEMBL29827331	0.78	GRM5 (0.42)	GRM5SYKMAPKAPK2EGFRAURKB
SCHEMBL23273849	0.78	GRM5 (0.42)	GRM5SYKMAPKAPK2EGFRAURKB
SCHEMBL27240040	0.76	GRM5 (0.41)	GRM5RORCMEN1LMNAKMT2A
SCHEMBL23288026	0.75	GRM5 (0.44)	GRM5RORCMAPKAPK2
SCHEMBL27240202	0.75	GRM5 (0.41)	GRM5MAPKAPK2MEN1LMNAKMT2A
SCHEMBL27240046	0.74	MEN1 (0.40)	GRM5MAPKAPK2MEN1LMNAKMT2A
SCHEMBL23287990	0.73	MEN1 (0.39)	GRM5MEN1LMNAKMT2ASMN1; SMN2
SCHEMBL27240259	0.73	GRM5 (0.38)	GRM5RORCMEN1LMNAKMT2A
SCHEMBL27240067	0.72	LCK (0.41)	GRM5MEN1LMNAKMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2021080013-A1	INHIBITORS OF TREK (TWIK RELATED K+ CHANNELS) CHANNEL FUNCTION	ONO PHARMACEUTICAL CO., LTD. (JP)	2021-04-29	—	—	WO	disclosed