Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | MLLT1 | Q03111 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30557195 | 1.00 | DNMT1 (0.49) | DNMT1MAPK14KDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL30557306 | 0.98 | DNMT1 (0.48) | DNMT1MAPK14KDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL23292102 | 0.98 | DNMT1 (0.48) | DNMT1MAPK14KDM4EALDH1A1HPGD | |
| SCHEMBL11018883 | 0.75 | DNMT1 (0.51) | DNMT1MAPK14KDM4ESCN5ATGFBR1 | |
| SCHEMBL15639155 | 0.75 | DNMT1 (0.48) | DNMT1MAPK14SCN5ATGFBR1ADORA2A | |
| SCHEMBL10957958 | 0.72 | DNMT1 (0.51) | DNMT1MAPK14KDM4EALDH1A1HPGD | |
| SCHEMBL11379662 | 0.72 | SCN5A (0.59) | DNMT1MAPK14ALDH1A1SCN5ATGFBR1 | |
| SCHEMBL1500118 | 0.71 | GRM1 (0.59) | DNMT1MAPK14SCN5ATGFBR1ADORA2A | |
| SCHEMBL15639173 | 0.71 | TGFBR1 (0.48) | DNMT1MAPK14ALDH1A1SCN5ATGFBR1 | |
| SCHEMBL15639501 | 0.69 | TGFBR1 (0.44) | DNMT1MAPK14SCN5ATGFBR1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3814360-A1 | HETEROARYL COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE | PTC Therapeutics, Inc. (US) | 2021-05-05 | — | — | EP | claimed |